ANTISITETASE SYNDROME: SERIES OF CASES DIAGNOSED IN A COMARCAL HOSPITAL

Abstract

Introduction: The antisynthetase syndrome is a rare autoimmune disease that affects multiple organs. It typically presents with polymyositis, interstitial lung disease, and antisynthetase autoantibodies. Fever, arthritis, and Raynaud's phenomenon are also common features. Various specific antibodies aid in diagnosis. Treatment involves the use of corticosteroids combined with other immunosuppressive agents.

Material and methods: Case series describing three patients with antisynthetase syndrome.

Results: Three cases of antisynthetase syndrome are presented, each exhibiting the classic triad of clinical manifestations. However, they presented with different specific antibodies and interstitial patterns. Each case required a different therapeutic approach with various immunosuppressive drugs. These cases underline the variability in clinical presentation and the need for individualized management of antisynthetase syndrome.

Conclusion: The antisynthetase syndrome is a rare condition that is important to consider in patients presenting with polymyositis and interstitial lung disease. Requesting antisynthetase antibodies testing is crucial for achieving an early diagnosis. This is essential for ensuring timely and appropriate therapeutic interventions, thereby improving the prognosis and quality of life for affected patients